Maintaining strong and healthy bones is essential for our wellbeing. Bone provides structural support and protection for our vital organs. Bone density and bone strength are key components of bone health and the most common metabolic bone disease is osteoporosis, a condition of weak and fragile bones.

Oxford Biosystems has been a supplier of products for the investigation of bone and cartilage metabolism for many years. Our products are developed and manufactured by internationally recognised manufacturers and supported by their technical expertise gained through collaboration with scientists around the world.

• Biomedica Medizinprodukte GmbH, Austria
• DIAsource Immunoassays, Belgium, part of the BioVendor Group
• IBL International GmbH, Germany, part of the Tecan Group
• Aidian Oy, Finland
• BioVendor Laboratorni medicina a. s., Czech Republic, part of the BioVendor Group
• Mediagnost Society for Research and Manufacturing of Diagnostika GmbH, Germany

Bones are continuously undergoing a dynamic process of resorption and absorption known as bone metabolism which is essential for the maintenance of healthy bone mass and micro-architecture. This remodelling process is tightly regulated, involving various hormones and factors.

The bone cycle consists of different phases and markers of bone metabolism can be categorized as markers of bone formation, markers of bone resorption and markers of the regulation of bone metabolism.

These biomarkers can be measured to assess bone health or monitor treatment in several clinical conditions:

• Bone metastases
• Peri- and post-menopause
• Chronic kidney disease (CKD)
• Growth hormone deficiency
• Osteoporosis
• Vascular or other soft tissue calcification
• Depressed bone formation in multiple myeloma

Oxford BioSystems offers an extensive range of kits and reagents for both clinical investigation and research in the field of bone and cartilage metabolism. Our range of ELISA and RIA kits includes:

• 25-hydroxyvitamin D (25(OH)D)
• 1,25-dihydroxyvitamin D (1,25(OH)2D)
• Free Vitamin D
• Parathyroid hormone (PTH)
• Sclerostin
• Periostin
• Osteoprotegerin (OPG)
• Free sRANKL
• Dickkopf-1 (DKK-1)
• Cathepsin K
• Semaphorin 4D
• FGF23 (Intact and C-Terminal kits)
• PINP (aminoterminal propeptide of type I procollagen)
• ICTP (carboxyterminal telopeptide of type I collagen)
• PIIINP (aminoterminal propeptide of type III procollagen)
• Osteopontin
• Osteocalcin
• Soluble α-Klotho
• Calcitonin
• Bone-specific Alkaline Phosphatase (BAP)

Please visit our Downloads page for specific brochures or contact us directly to discuss your specific assay requirements.